Phthalocyanine-BODIPY dye: synthesis, characterization, and utilization for pattern recognition of CYFRA 21-1 in whole blood samples

Basit Öğe Kaydı
dc.contributor.authorStefan-van Staden, Raluca-Ioana
dc.contributor.authorComnea-Stancu, Ionela Raluca
dc.contributor.authorYanik, Hulya
dc.contributor.authorGoksel, Meltem
dc.contributor.authorAlexandru, Anghel
dc.contributor.authorDurmuş, Mahmut
dc.date.accessioned2025-10-29T11:33:21Z
dc.date.issued2017
dc.departmentFakülteler, Temel Bilimler Fakültesi, Kimya Bölümü
dc.description.abstractPhthalocyanine-BODIPY dye (BODIPY = boron dipyrromethene) was synthesized, fully characterized, and used for molecular recognition of CYFRA 21-1, a lung cancer biomarker, from whole blood samples. Thin films of three magnesium oxides ((MgO) (n) , where n = 8, 9, or 10)) were deposited on a paper substrate, and they were immersed in a solution of phthalocyanine-BODIPY dye (1.17 x 10(-3) mol/L) for the design of stochastic sensors. Limits of determination of picograms per milliliter magnitude order were recorded for the proposed stochastic sensors. CYFRA 21-1 was reliably identified and determined with recoveries higher than 95% and RSD lower than 1% in whole blood samples.
dc.description.sponsorshipSectorial Operational Programme Human Resources Development of the Ministry of European Funds [POSDRU/159/1.5/S/132395]
dc.description.sponsorship[123/2011]
dc.description.sponsorshipThis work was supported by a project within the frame PNII, Ideas 123/2011. IR Comnea-Stancu is thankful for the funding from the Sectorial Operational Programme Human Resources Development 2007-2013 of the Ministry of European Funds through Financial Agreement POSDRU/159/1.5/S/132395.
dc.identifier.doi10.1007/s00216-017-0560-y
dc.identifier.endpage6203
dc.identifier.issn1618-2642
dc.identifier.issn1618-2650
dc.identifier.issue26
dc.identifier.orcid0000-0002-5418-5915
dc.identifier.orcid0000-0002-7083-6933
dc.identifier.orcid0000-0001-8244-2483
dc.identifier.pmid28852796
dc.identifier.scopus2-s2.0-85028747620
dc.identifier.scopusqualityQ1
dc.identifier.startpage6195
dc.identifier.urihttps://doi.org/10.1007/s00216-017-0560-y
dc.identifier.urihttps://hdl.handle.net/20.500.14854/12346
dc.identifier.volume409
dc.identifier.wosWOS:000411709000015
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofAnalytical and Bioanalytical Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20251020
dc.subjectCYFRA 21-1
dc.subjectStochastic sensors
dc.subjectLung cancer
dc.subjectPhthalocyanine
dc.subjectBODIPY
dc.titlePhthalocyanine-BODIPY dye: synthesis, characterization, and utilization for pattern recognition of CYFRA 21-1 in whole blood samples
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Temel Bilimler Fakültesi Koleksiyonu