Preparation of androstanes related to aphidicolin

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dc.contributor.authorUyanik, Cavit
dc.contributor.authorYildirim, Kudret
dc.contributor.authorMalay, Aslihan
dc.contributor.authorHanson, James R.
dc.contributor.authorHitchcock, Peter B.
dc.date.accessioned2025-10-29T11:13:23Z
dc.date.issued2007
dc.departmentFakülteler, Temel Bilimler Fakültesi, Kimya Bölümü
dc.description.abstractThe preparation of 3 alpha, 4 alpha, 17 beta-trihydroxy-, 3 alpha, 4 alpha, 16 alpha, 17 alpha- and 2 alpha, 3 alpha, 16 alpha, 17 alpha-tetrahydroxy-5 alpha- androstane derivatives (5, 11, 18) from testosterone as steroidal analogues of diterpenoid inhibitor of DNA polymerase a, aphidicolin, is described. The crystal structure of 5 alpha- androstane-3 alpha, 4 alpha, 17 beta- triyl triacetate (6) is reported.
dc.identifier.doi10.1135/cccc20071545
dc.identifier.endpage1552
dc.identifier.issn0010-0765
dc.identifier.issue11
dc.identifier.orcid0000-0002-7889-5903
dc.identifier.scopus2-s2.0-39149142532
dc.identifier.scopusqualityN/A
dc.identifier.startpage1545
dc.identifier.urihttps://doi.org/10.1135/cccc20071545
dc.identifier.urihttps://hdl.handle.net/20.500.14854/6737
dc.identifier.volume72
dc.identifier.wosWOS:000252670000006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherInst Organic Chem And Biochem
dc.relation.ispartofCollection of Czechoslovak Chemical Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20251020
dc.subjectaphidicolin
dc.subjectsteroids
dc.subjectandrostanes
dc.subjectditerpenoids
dc.subjectcatalytic hydroxylation
dc.subjectX-ray crystallography
dc.subjectDNA polymerase inhibitors
dc.titlePreparation of androstanes related to aphidicolin
dc.typeArticle

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