Gold Nanoparticles and Antimicrobial Peptides: A Novel Combination

Abstract

This article examines the diverse conjugation forms of AMP-AuNP nanostructures that arise from the amalgamation of antimicrobial peptides (AMPs) and gold nanoparticles (AuNPs), as well as their prospective utility in the field of biomedicine. AMPs are a class of naturally occurring microbicidal compounds that are recognized for their wide range of inhibitory effects and distinctive modes of operation. The utilization of AuNPs in diverse biomedical applications is facilitated through the application of nanotechnology. AMP-AuNP nanostructures exhibit diverse features through the utilization of molecular linkage techniques. The aforementioned qualities encompass the ability to expedite the process of wound healing, facilitate precise targeting through the incorporation of DNA aptamers, serve as a means for bacterial imaging, enable the use of photothermal therapy, and contribute to the advancement of prospective treatments for fungal infections. The utilization of these synthesized antimicrobial gold nanostructures in many biomedical applications holds significant promise for advancing treatments and enhancing disease management. Antimicrobial peptides (AMPs) and gold nanoparticles (AuNPs) have strong potential in the fight against infections with their antimicrobial activity. The combined use of AMPs and AuNPs represents a promising approach for the development of new and more effective antimicrobial therapies against resistant bacteria. This review provides a thorough analysis of the incorporation of AMPs and AuNPs. It examines the characteristics of AuNP-AMPs, their synergistic interactions, the significance of this integration, and potential application areas, highlighting recent developments in the literature. image