In vivo phototoxic effects of a tetraethyleneglycol-substituted Zn phthalocyanine in tumor bearing rats at an enzymatic level

Abstract

A study of the enzymatic changes following the photodynamic treatment on CCL-18-tumor implanted Wistar albino rats. TEG-Pc, a Zn(II) phthalocyanine tetra substituted in non-peripheral position by tetraethylene glycol chains, proved to have good efficiency during in vitro photodynamic experiments. Its in vivo phototoxic effects have been investigated in tumor-bearing Wistar albino rats at an enzymatic level. The evolution of different oxidative markers are reviewed 6 h after the treatment.