Tyrosine conjugated zinc(II) phthalocyanine for photodynamic therapy: Synthesis and photophysicochemical properties

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dc.contributor.authorAliosman, Meliha
dc.contributor.authorGoksel, Meltem
dc.contributor.authorMantareva, Vanya
dc.contributor.authorStoineva, Ivanka
dc.contributor.authorDurmuş, Mahmut
dc.date.accessioned2025-10-29T11:26:13Z
dc.date.issued2017
dc.departmentFakülteler, Temel Bilimler Fakültesi, Kimya Bölümü
dc.description.abstractBiologically active photosensitizers with long absorption wavelength are among the new generation drugs for potential application in photodynamic therapy (PDT). This study presents a new phthalocyanine photosensitizer functionalized with amino acid for application in PDT. This photosensitizer, tetra-(4-tyrosylamido) phenoxy substituted zinc(II) phthalocyanine (ZnPcTyr), was synthesized and chemically characterized. The properties of electronic absorption, fluorescence, photostability, and singlet oxygen generation were studied. The obtained photophysicochemical characteristics suggested that this newly synthesized tyrosine conjugated zinc(II) phthalocyanine has promising potential as photosensitizer for photodynamic therapy. (C) 2016 Elsevier B.V. All rights reserved.
dc.description.sponsorshipTUBITAK [2216]
dc.description.sponsorshipProgram for career development of young scientist, Bulgarian Academy of Sciences [150]
dc.description.sponsorshipMA thanks for the fellowship of TUBITAK, 2216 Research Fellowship Programme and the Program for career development of young scientist (project No. 150), Bulgarian Academy of Sciences.
dc.identifier.doi10.1016/j.jphotochem.2016.10.037
dc.identifier.endpage106
dc.identifier.issn1010-6030
dc.identifier.issn1873-2666
dc.identifier.orcid0000-0002-7841-0910
dc.identifier.scopus2-s2.0-84995772057
dc.identifier.scopusqualityQ1
dc.identifier.startpage101
dc.identifier.urihttps://doi.org/10.1016/j.jphotochem.2016.10.037
dc.identifier.urihttps://hdl.handle.net/20.500.14854/10144
dc.identifier.volume334
dc.identifier.wosWOS:000390512700011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Sa
dc.relation.ispartofJournal of Photochemistry and Photobiology A-Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20251020
dc.subjectPhotodynamic therapy
dc.subjectTyrosine
dc.subjectZn(II) phthalocyanine
dc.subjectFluorescence
dc.subjectSinglet oxygen
dc.subjectPhotostability
dc.titleTyrosine conjugated zinc(II) phthalocyanine for photodynamic therapy: Synthesis and photophysicochemical properties
dc.typeArticle

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