Study of the electronic and structural features characteristic of 4,5-dihydro-1-phenyl-1H-2,4-benzodiazepines demonstrating antiarrhythmic activity

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dc.contributor.authorShvets, N
dc.contributor.authorTerletskaya, A
dc.contributor.authorDimoglo, A
dc.contributor.authorChumakov, Y
dc.date.accessioned2025-10-29T11:21:00Z
dc.date.issued1999
dc.departmentGebze Teknik Üniversitesi
dc.description2nd European Conference on Computational Chemistry (EUCO-CC2) -- SEP 02-06, 1997 -- LISBON, PORTUGAL
dc.description.abstractThe relationships between the structure of the compounds and their antiarrhythmic activities have been investigated in a series of 4,5-dihydro-1-phenyl-1H-2,4-benzodiazepines (54 compounds) by means of the electron-topological method. As a result of the approach applied, two fragments characteristic of two kinds of activities demonstrated by the compounds have been found and studied. The system of prognostication developed on the base of the data obtained is being used for screening and search of new active antiarrhythmic agents. (C) 1999 Elsevier Science B.V. All rights reserved.
dc.description.sponsorshipFederat European Chem Soc,Portguese Chem Soc,European Commiss
dc.identifier.doi10.1016/S0166-1280(98)00399-6
dc.identifier.endpage110
dc.identifier.issn0166-1280
dc.identifier.issue1-2
dc.identifier.startpage105
dc.identifier.urihttps://doi.org/10.1016/S0166-1280(98)00399-6
dc.identifier.urihttps://hdl.handle.net/20.500.14854/8840
dc.identifier.volume463
dc.identifier.wosWOS:000079425800015
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofJournal of Molecular Structure-Theochem
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20251020
dc.subjectantiarrhythmic activity
dc.subjectbenzodiazepines
dc.subjectelectron-topological method
dc.subjectstructure-activity relationships evaluation
dc.titleStudy of the electronic and structural features characteristic of 4,5-dihydro-1-phenyl-1H-2,4-benzodiazepines demonstrating antiarrhythmic activity
dc.typeConference Object

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