Binuclear cyanido complexes containing [Pt(CN)4]2- building block: Synthesis, crystal structures, magnetic properties and anticancer activities

Abstract

Five new complexes of composition [Ni(N-bishydeten)Pt(CN)(4)] (1), [Ni(N-bishydeten)(2)][Pt(CN)(4)] (2), [Cu (N-bishydeten)Pt(CN)(4)] (3), [Cu(N-bishydeten)(2)][Pt(CN)(4)] (4) and [Cd(N-bishydeten)(2)][Pt(CN)(4)] (5) (N-bishydeten = N,N-bis(2-hydroxyethyl)-ethylenediamine) have been obtained and characterized by IR and EPR spectroscopies, elemental and thermal analysis and magnetic measurements. X-ray studies of 2 and 3 exhibited different structures and two different coordination modes of N-bishydeten ancillary ligand with a ratio of M:L. While N-bishydeten acts as a tetradentate with N', N', O and O' atoms in a molar ratio of 1:1 formed 2,2-CT-type zigzag chain for 3, it behaves tridentate ligand by ending up with six coordinated Ni-II center in a complex salt by using 1:2 M ratio for 2. None of the 1 and 3 complexes produced in this study showed sufficient anticancer activity but all did exhibit apoptotic properties and one of them also performed low cytotoxic activity against cell tested. (C) 2016 Elsevier B.V. All rights reserved.