Zn phthalocyanine conjugation to H2-ul aptamer for HER2-targeted breast cancer photodynamic therapy: Design, optimization and properties

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dc.contributor.authorAlpugan, Serkan
dc.contributor.authorTopkaya, Derya
dc.contributor.authorAtilla, Devrim
dc.contributor.authorAhsen, Vefa
dc.contributor.authorNiazi, Javed H.
dc.contributor.authorDumoulin, Fabienne
dc.date.accessioned2025-10-29T11:13:08Z
dc.date.issued2017
dc.departmentFakülteler, Temel Bilimler Fakültesi, Kimya Bölümü
dc.description.abstractTetrasulfonated Zn phthalocyanine was conjugated to a ssDNA aptamer moiety to produce a HER2 targeted photosensitizer. The tetraconjugate obtained was subjected to purification and the monoconjugate was successfully isolated, purified and characterized. This monoconjugate retained the ability to bind to HER2 as well as the potency to generate singlet oxygen.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [112T670, CM1105]
dc.description.sponsorshipFunding from the Scientific and Technological Research Council of Turkey (TUBITAK) is acknowledged (project 112T670 coupled to the COST Action CM1105).
dc.identifier.doi10.1142/S1088424617500973
dc.identifier.endpage892
dc.identifier.issn1088-4246
dc.identifier.issn1099-1409
dc.identifier.issue12
dc.identifier.orcid0000-0002-0388-8338
dc.identifier.orcid0000-0002-8395-9676
dc.identifier.orcid0000-0002-2529-2105
dc.identifier.scopus2-s2.0-85041493508
dc.identifier.scopusqualityQ3
dc.identifier.startpage887
dc.identifier.urihttps://doi.org/10.1142/S1088424617500973
dc.identifier.urihttps://hdl.handle.net/20.500.14854/6620
dc.identifier.volume21
dc.identifier.wosWOS:000424489600014
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWorld Scientific Publ Co Pte Ltd
dc.relation.ispartofJournal of Porphyrins and Phthalocyanines
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20251020
dc.subjectcancer targeting
dc.subjectphotodynamic therapy
dc.subjectHER2
dc.subjectaptamer
dc.subjectphthalocyanine
dc.titleZn phthalocyanine conjugation to H2-ul aptamer for HER2-targeted breast cancer photodynamic therapy: Design, optimization and properties
dc.typeArticle

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