4-Aminoantipyrine-derived Schiff base substituted novel symmetrical zinc (II) phthalocyanine photosensitizers: Design, synthesis, photophysical, and photochemical properties for photodynamic therapy of cancer

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dc.contributor.authorYalazan, Halise
dc.contributor.authorOmeroglu, Ipek
dc.contributor.authorDurmuş, Mahmut
dc.contributor.authorKantekin, Halit
dc.date.accessioned2025-10-29T11:27:10Z
dc.date.issued2025
dc.departmentFakülteler, Temel Bilimler Fakültesi, Kimya Bölümü
dc.description.abstractIn this study, new Zn-phthalocyanine compounds (ANTS-ZnPcsp/np), peripherally and non-peripherally substituted with 4-aminoantipyrine-derived Schiff base, were synthesized and characterized by FT-IR, NMR, MALDI-TOF, and UV-Vis spectroscopic techniques. The photophysical and photochemical properties of these compounds were investigated. The fluorescence quantum yield values were found to be 0.11 and 0.05 in DMSO for ANTS-ZnPcp and ANTS-ZnPcnp, respectively. The singlet oxygen quantum yield values of these phthalocyanines were obtained as 0.53 for ANTS-ZnPcp and 0.27 for ANTS-ZnPcnp. According to the results, both phthalocyanine derivatives are considered to be suitable photosensitizers for cancer treatment by photodynamic therapy (PDT) method.
dc.description.sponsorshipOffice of Scientific Research Projects of Karadeniz Technical University [FBA-2024-16009]
dc.description.sponsorshipThis work was supported by Office of Scientific Research Projects of Karadeniz Technical University. Project number: FBA-2024-16009.
dc.identifier.doi10.1016/j.inoche.2025.115125
dc.identifier.issn1387-7003
dc.identifier.issn1879-0259
dc.identifier.scopus2-s2.0-105011193686
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.inoche.2025.115125
dc.identifier.urihttps://hdl.handle.net/20.500.14854/10617
dc.identifier.volume181
dc.identifier.wosWOS:001541339200006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInorganic Chemistry Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20251020
dc.subject4-Aminoantipyrine
dc.subjectSchiff base
dc.subjectPhthalocyanine
dc.subjectPhotodynamic therapy
dc.subjectPhotophysical
dc.subjectPhotochemical
dc.title4-Aminoantipyrine-derived Schiff base substituted novel symmetrical zinc (II) phthalocyanine photosensitizers: Design, synthesis, photophysical, and photochemical properties for photodynamic therapy of cancer
dc.typeArticle

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