Human Transferrin Detection Through a Mass-Sensitive Biosensor Utilizing ZnO Thin-Films via Atomic Layer Deposition

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dc.contributor.authorAlev, Onur
dc.contributor.authorKilic, Alp
dc.contributor.authorCoban, Muzeyyen
dc.contributor.authorTokyay, Begum K.
dc.contributor.authorBuyukkose, Serkan
dc.contributor.authorOzturk, Selma
dc.contributor.authorOzturk, Zafer Z.
dc.date.accessioned2025-10-29T11:15:39Z
dc.date.issued2024
dc.departmentFakülteler, Temel Bilimler Fakültesi, Fizik Bölümü
dc.description.abstractIn this letter, we present the first example of a zinc oxide (ZnO) thin film grown by atomic layer deposition method (ALD) on a quartz crystal microbalance (QCM) for the detection of human transferrin (hTF) molecule. Morphological, structural, and optical properties of ZnO thin film were investigated by scanning electron microscopy, atomic force microscopy, X-ray photoelectron spectroscopy, X-ray diffraction spectroscopy, ultraviolet-visible spectroscopy, and photoluminescence. For biosensor measurements, ZnO/QCM sensors were modified with antitransferrin to obtain selectivity against hTF. Mass-sensitive biosensor tests were carried out using two different measurement methods: dip-dry and flow-cell. It was observed that antitransferrin immobilized ZnO/QCM sensor detected hTF molecule in the range of 100-1000 ng. Moreover, the sensors exhibited better performance in the dip-dry method than the flow-cell method. ZnO-coated QCM exhibited good mass-sensitive performance, which make it a suitable sensor platform for biosensor applications.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [120Z840]
dc.description.sponsorshipThis work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) under Grant 120Z840. The authors would like to thank Prof. Dr.Mehmet Ali Ebeoglu and Asst. Prof. F & imath;rat Aydemir from Dumlupinar University for providing an optimized oscillator circuit.
dc.identifier.doi10.1109/LSENS.2024.3414659
dc.identifier.issn2475-1472
dc.identifier.issue7
dc.identifier.orcid0009-0003-4771-6401
dc.identifier.orcid0000-0003-2065-2965
dc.identifier.orcid0000-0002-5301-679X
dc.identifier.orcid0000-0003-2542-8110
dc.identifier.scopus2-s2.0-85196083992
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1109/LSENS.2024.3414659
dc.identifier.urihttps://hdl.handle.net/20.500.14854/7206
dc.identifier.volume8
dc.identifier.wosWOS:001256359800007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherIEEE-Inst Electrical Electronics Engineers Inc
dc.relation.ispartofIEEE Sensors Letters
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20251020
dc.subjectMass sensors
dc.subjectatomic layer deposition (ALD)
dc.subjectbiosensor
dc.subjecthuman transferrin (hTF)
dc.subjectquartz crystal microbalance (QCM)
dc.subjectzinc oxide (ZnO)
dc.titleHuman Transferrin Detection Through a Mass-Sensitive Biosensor Utilizing ZnO Thin-Films via Atomic Layer Deposition
dc.typeArticle

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