Electronic-Topological Study of Structurally Diverse Cyclooxygenase-2 Inhibitors

Basit Öğe Kaydı
dc.contributor.authorDimoglo, A.
dc.contributor.authorSim, E.
dc.contributor.authorShvets, N.
dc.contributor.authorAhsen, V.
dc.date.accessioned2025-10-29T11:09:40Z
dc.date.issued2003
dc.departmentGebze Teknik Üniversitesi
dc.description.abstractA large series of cyclooxygenase-2 (COX-2) inhibitors with diverse skeletons were investigated by means of the Electronic-Topological Method. A system for the COX-2 inhibitor activity prognostication was built with 6 pharmacophores and 6 anti-pharmacophores. The forecasting ability of the system was also tested on different structures, which differ from those that characterize the series studied.
dc.description.sponsorshipTUBITAK
dc.description.sponsorshipA gratitude is expressed to TUBITAK by E.S. for the financial support. All authors are also grateful to Dr. M. Goktepe and H. Gunduz from FAKO pharmaceuticals for their interest to this study and help.
dc.identifier.doi10.2174/1389557033488060
dc.identifier.endpage294
dc.identifier.issn1389-5575
dc.identifier.issn1875-5607
dc.identifier.issue4
dc.identifier.pmid12678822
dc.identifier.scopus2-s2.0-0038542932
dc.identifier.scopusqualityQ1
dc.identifier.startpage281
dc.identifier.urihttps://doi.org/10.2174/1389557033488060
dc.identifier.urihttps://hdl.handle.net/20.500.14854/5943
dc.identifier.volume3
dc.identifier.wosWOS:000210553300002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofMini-Reviews in Medicinal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20251020
dc.subjectCOX-2
dc.subjectNSAIDs
dc.subjectStructure-Activity Relationships (SAR)
dc.titleElectronic-Topological Study of Structurally Diverse Cyclooxygenase-2 Inhibitors
dc.typeReview Article

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu