Palladium catalyzed cross-coupling of 3-methylthiophene-2-carbonyl chloride with aryl/het-aryl boronic acids: a convenient method for synthesis of thienyl ketones
| dc.contributor.author | Rizwan, Kainat F. | |
| dc.contributor.author | Karakaya, Idris | |
| dc.contributor.author | Zubair, Muhammad Waqas | |
| dc.contributor.author | Rasool, Nasir | |
| dc.date.accessioned | 2025-10-29T12:08:03Z | |
| dc.date.issued | 2022 | |
| dc.department | Gebze Teknik Üniversitesi | |
| dc.description.abstract | Bi-aryl ketones are important motifs in large number of pharmaceutical compounds and natural products. A protocol for the synthesis of thienyl ketones has been developed via Pd (0) catalyzed cross-coupling reaction. The desired thienyl ketones (3a-x) were synthesized by cross coupling of 3-methylthiophene-2-carbonyl chloride with variety of aryl/heteroaryl-boronic acids in good to excellent yields (46–91%) under mild conditions (1.5 eq Cs<inf>2</inf>CO<inf>3</inf> at 50 °C). Different functional groups were well tolerated under the developed reaction conditions. © 2024 Elsevier B.V., All rights reserved. | |
| dc.identifier.doi | 10.1080/17415993.2022.2079379 | |
| dc.identifier.endpage | 506 | |
| dc.identifier.issn | 1741-5993 | |
| dc.identifier.issn | 1741-6000 | |
| dc.identifier.issue | 5 | |
| dc.identifier.scopus | 2-s2.0-85131352755 | |
| dc.identifier.scopusquality | Q2 | |
| dc.identifier.startpage | 494 | |
| dc.identifier.uri | https://doi.org/10.1080/17415993.2022.2079379 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14854/14285 | |
| dc.identifier.volume | 43 | |
| dc.indekslendigikaynak | Scopus | |
| dc.language.iso | en | |
| dc.publisher | Taylor and Francis Ltd. | |
| dc.relation.ispartof | Journal of Sulfur Chemistry | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.snmz | KA_Scopus_20251020 | |
| dc.subject | arylboronic acid | |
| dc.subject | Coupling | |
| dc.subject | palladium | |
| dc.subject | synthesis | |
| dc.subject | thienyl ketone | |
| dc.title | Palladium catalyzed cross-coupling of 3-methylthiophene-2-carbonyl chloride with aryl/het-aryl boronic acids: a convenient method for synthesis of thienyl ketones | |
| dc.type | Article |
