Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Metformin Release

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dc.contributor.authorSharma, Manoj B.
dc.contributor.authorKap, Ozlem
dc.contributor.authorAbdelmohsen, Hend A. M.
dc.contributor.authorAshton, Mark D.
dc.contributor.authorHarper, Garry R.
dc.contributor.authorFirlak, Melike
dc.contributor.authorAaltonen, Jasmine E.
dc.date.accessioned2025-10-29T11:34:12Z
dc.date.issued2023
dc.departmentFakülteler, Temel Bilimler Fakültesi, Kimya Bölümü
dc.description.abstractThe release of metformin, a drug used in the treatment of cancer and diabetes, from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel-based microneedle patches is demonstrated in vitro. Tuning the composition of the pHEMA hydrogels enables preparation of robust microneedle patches with mechanical properties such that they would penetrate skin (insertion force of a single microneedle to be & AP;40 N). Swelling experiments conducted at 20, 35, and 60 & DEG;C show temperature-dependent degrees of swelling and diffusion kinetics. Drug release from the pHEMA hydrogel-based microneedles is fitted to various models (e.g., zero order, first order, second order). Such pHEMA microneedles have potential application for transdermal delivery of metformin for the treatment of aging, cancer, diabetes, etc.
dc.description.sponsorshipIndian Ministry of Social Justice amp
dc.description.sponsorshipEmpowerment and the High Commission of India in London
dc.description.sponsorshipBritish Council and the Scientific and Technological Research Council of Turkey (TUBITAK) [11015/75/2017-SCD-V]
dc.description.sponsorshipUK-Turkey Institutional Links programme
dc.description.sponsorshipScientific Research Projects Coordination unit of Izmir Katip Celebi University [116E934, 336872]
dc.description.sponsorshipBritish Council Newton-Mosharafa Fund [2018-OEDL-MUEMF-0021]
dc.description.sponsorshipUKRI Engineering and Physical Sciences Research Council (EPSRC) [NMM28/20]
dc.description.sponsorshipRoyal Society for a Newton International Fellowship [EP/R003823/1]
dc.description.sponsorshipBritish Council of Greece [NF151479]
dc.description.sponsorshipMinistry of Education of Saudi Arabia [RG160449]
dc.description.sponsorshipRoyal Embassy of Saudi Arabia Cultural Bureau
dc.description.sponsorship[KAU1520]
dc.description.sponsorship[00012727]
dc.description.sponsorshipEPSRC [EP/R003823/1] Funding Source: UKRI
dc.description.sponsorshipThis research was funded by a variety of sources, and the authors acknowledge: the Indian Ministry of Social Justice & Empowerment and the High Commission of India in London for a PhD Studentship for M.B.S. (Grant Reference: 11015/75/2017-SCD-V); the British Council and the Scientific and Technological Research Council of Turkey (TUBITAK) for support of OE.K., V.K., N.H., and J.G.H., via the UK-Turkey Institutional Links programme (Turkey grant reference: 116E934. UK grant reference: 336872); the Scientific Research Projects Coordination unit of Izmir Katip Celebi University for support of OE.K., V.K., and N.H. (Project no. 2018-OEDL-MUEMF-0021); the British Council Newton-Mosharafa Fund PhD Programme for a studentship to support H.A.M.A. (Grant Reference: NMM28/20); UKRI Engineering and Physical Sciences Research Council (EPSRC) for support of G.R.H. (Grant reference: EP/R003823/1); the Royal Society for a Newton International Fellowship to support M.F. (Grant Reference: NF151479) and a Research Grant to support J.G.H. (Grant reference: RG160449); the British Council of Greece for the IELTS Award 2017 for V.K.O.; the Ministry of Education of Saudi Arabia and the Royal Embassy of Saudi Arabia Cultural Bureau for support of A. D. A. (Grant reference: KAU1520, Student ID 00012727).
dc.identifier.doi10.1002/gch2.202300002
dc.identifier.issn2056-6646
dc.identifier.issue8
dc.identifier.orcid0000-0003-0655-2167
dc.identifier.orcid0000-0002-2827-907X
dc.identifier.orcid0009-0008-5398-1064
dc.identifier.orcid0000-0001-9646-0850
dc.identifier.orcid0000-0002-3164-1981
dc.identifier.orcid0009-0004-6561-4844
dc.identifier.orcid0000-0003-1353-0329
dc.identifier.pmid37635699
dc.identifier.scopus2-s2.0-85163852344
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/gch2.202300002
dc.identifier.urihttps://hdl.handle.net/20.500.14854/12743
dc.identifier.volume7
dc.identifier.wosWOS:001022238500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofGlobal Challenges
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20251020
dc.subjectaging
dc.subjectcancer
dc.subjectdiabetes
dc.subjectdrug delivery
dc.subjecthydrogels
dc.subjectmicroneedles
dc.titlePoly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Metformin Release
dc.typeArticle

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