Investigation of photophysical, photochemical and bovine serum albumin binding properties of novel water-soluble zwitterionic zinc phthalocyanine complexes

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dc.contributor.authorGol, Cem
dc.contributor.authorDurmuş, Mahmut
dc.date.accessioned2025-10-29T11:22:40Z
dc.date.issued2012
dc.departmentFakülteler, Temel Bilimler Fakültesi, Kimya Bölümü
dc.description.abstractThe non-peripherally tetra-(1a), peripherally tetra-(2a) and peripherally octa-(3a) zwitterionic zinc(II) phthalocyanine complexes bearing 2-(N-propanesulfonic acid)mercaptopyridine groups have been synthesized for the first time. These novel complexes have been characterized by elemental analysis, UV-vis, IR and H-I NMR spectroscopy and mass spectra. These zwitterionic complexes show excellent solubility in water, which makes them candidate photosensitizers for use in photodynamic therapy (PDT) of cancer. The photophysical (fluorescence quantum yields and lifetimes) and photochemical (singlet oxygen and photodegradation quantum yields) properties of synthesized zwitterionic zinc(II) phthalocyanine complexes were investigated in DMSO and phosphate buffered solution (PBS). This study also presented the water soluble zwitterionic zinc(II) phthalocyanines strongly bind to blood plasma proteins such as bovine serum albumin (BSA). (C) 2012 Elsevier B.V. All rights reserved.
dc.description.sponsorshipGebze Institute of Technology [BAP-2007-A-01]
dc.description.sponsorshipThis work was supported by Scientific Research Project of Gebze Institute of Technology (BAP-2007-A-01).
dc.identifier.doi10.1016/j.synthmet.2012.02.017
dc.identifier.endpage613
dc.identifier.issn0379-6779
dc.identifier.issue7-8
dc.identifier.orcid0000-0001-9258-1866
dc.identifier.scopus2-s2.0-84858717995
dc.identifier.scopusqualityQ1
dc.identifier.startpage605
dc.identifier.urihttps://doi.org/10.1016/j.synthmet.2012.02.017
dc.identifier.urihttps://hdl.handle.net/20.500.14854/9046
dc.identifier.volume162
dc.identifier.wosWOS:000303976500008
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Sa
dc.relation.ispartofSynthetic Metals
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20251020
dc.subjectPhthalocyanine
dc.subjectZinc
dc.subjectZwitterionic
dc.subjectWater soluble
dc.subjectPhotosensitizer
dc.titleInvestigation of photophysical, photochemical and bovine serum albumin binding properties of novel water-soluble zwitterionic zinc phthalocyanine complexes
dc.typeArticle

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