Biotinylated-cationic zinc(II) phthalocyanine towards photodynamic therapy [2]

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dc.contributor.authorGhazal, B.
dc.contributor.authorKaya, Esra Nur
dc.contributor.authorHusain, Ali A.
dc.contributor.authorGanesan, Asaithampi
dc.contributor.authorDurmuş, Mahmut Esad
dc.contributor.authorMakhseed, Saad M.
dc.date.accessioned2025-10-29T12:08:40Z
dc.date.issued2019
dc.departmentFakülteler, Temel Bilimler Fakültesi, Kimya Bölümü
dc.description.abstractTargeting biotin receptors in cancer cells can improve specifying of photosensitizers (PSs) for cancer treatment by photodynamic therapy (PDT) applications. Consequently, there has been extensive research focusing mainly on the design of PSs with optimized pharmaceutical properties and better targeting toward cancer cells. Herein a tailored mono-biotinylated zinc(II) phthalocyanine (Pc-1) substituted with six phenoxy-bis(triazolyl) substituents has been synthesized. This Pc-1 has been further modified to its cationic version (Pc-2) through quaternizing of the triazole moiety to gain water solubility. Both non-ionic zinc(II) phthalocyanine (Pc-1) and its cationic derivative (Pc-2) were characterized by standard spectroscopic techniques, namely; FT-IR, 1H and 13C NMR, UV-Vis and MALDI-TOF, and by elemental analysis. The photophysical and photochemical properties were evaluated in DMSO for the non-ionic Pc-1 and in both DMSO and water for the cationic Pc-2. © 2019 Elsevier B.V., All rights reserved.
dc.identifier.doi10.1142/S1088424618501158 [2]
dc.identifier.endpage55
dc.identifier.issn1099-1409
dc.identifier.issn1088-4246
dc.identifier.issue1-2
dc.identifier.scopus2-s2.0-85059189102
dc.identifier.scopusqualityQ3
dc.identifier.startpage46
dc.identifier.urihttps://doi.org/10.1142/S1088424618501158 [2]
dc.identifier.urihttps://hdl.handle.net/20.500.14854/14620
dc.identifier.volume23
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWorld Scientific Publishing Co. Pte Ltd wspc@wspc.com.sg
dc.relation.ispartofJournal of Porphyrins and Phthalocyanines
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20251020
dc.subjectphotochemical
dc.subjectphotodynamic therapy (PDT)
dc.subjectphotophysical
dc.subjectphotosensitizer (PS)
dc.subjectphthalocyanine (Pc)
dc.titleBiotinylated-cationic zinc(II) phthalocyanine towards photodynamic therapy [2]
dc.typeArticle

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