Antimicrobial Properties of Azole Functional Silica Nanocomposites

Abstract

Silica nanoparticles have become more attractive due to their surface characteristics, versatility, biocompatibility, and morphological and physicochemical properties. For this reason, their use in biological applications has been expanding in recent years. In this study, after functionalizing silica nanoparticles with glycidyl methacrylate monomer, nanocomposites were formed by attaching 1,2,4-Triazole, 3-Amino-1,2,4-Triazole, and 5-Aminotetrazole particles to the surface. Notably, the thermal degradation temperature of all nanocomposites was determined to surpass 200 degrees C. However, it is worth mentioning that despite the favorable water uptake rates observed for MT(7.64 %) and M3(5.98 %) nanocomposites, MT did not exhibit resistance against Fenton chemicals and experienced degradation. It is important to note that the material loss in M3 nanocomposites is minimal, measuring less than 1 %. In order to reveal the antifungal and antibacterial activity of the synthesized nanoparticles, Minimum inhibitory concentration(MIC), as well as Minimum Fungicidal Concentration(MFC) against the yeast strain Saccharomyces cerevisiae, and Minimum Bactericidal Concentration(MBC) values against bacteria strains, Staphylococcus aureus, Enterococcus faecalis and Escherichia coli were determined. The findings of the study indicated that MP, M3, and M5 nanocomposites displayed a moderate level of antibacterial activity. It is noteworthy, however, that the antibacterial activity diminished when triazole was combined with MP at concentrations exceeding 100 mg/mL. In this study, after functionalizing silica nanoparticles with glycidyl methacrylate monomer, nanocomposites were formed by attaching 1,2,4-Triazole, 3-Amino-1,2,4-Triazole, and 5-Aminotetrazole particles to the surface. Azole groups provide antimicrobial effects to the nanocomposites.image