Assessing the Dual Activity of a Chalcone-Phthalocyanine Conjugate: Design, Synthesis, and Antivascular and Photodynamic Properties

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dc.contributor.authorTuncel, Sinem
dc.contributor.authorTrivella, Aurelien
dc.contributor.authorAtilla, Devrim
dc.contributor.authorBennis, Khalil
dc.contributor.authorSavoie, Huguette
dc.contributor.authorAlbrieux, Florian
dc.contributor.authorDelort, Laetitia
dc.date.accessioned2025-10-29T11:20:26Z
dc.date.issued2013
dc.departmentFakülteler, Temel Bilimler Fakültesi, Kimya Bölümü
dc.description.abstractPhotodynamic therapy (PDT) and vascular-disrupting agents (VDA) each have their advantages in the treatment of solid tumors, but also present drawbacks. In PDT, hypoxia at the center of the tumor limits conversion of molecular oxygen into singlet oxygen, while VDAs are deficient at affecting the rim of the tumor. A phthalocyanine-chalcone conjugate combining the VDA properties of chalcones with the PDT properties of phthalocyanines was designed to address these deficiencies. Its vascular targeting, photophysical, photochemical, photodynamic activities are reported herein.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [109M356/26268ZM]
dc.description.sponsorshipFrench Embassy in Turkey [109M356/26268ZM]
dc.description.sponsorshipRegional Council of Auvergne (Conseil Regional d'Auvergne)
dc.description.sponsorshipEuropean Fund for Regional Economic Development (FEDER)
dc.description.sponsorshipThe Scientific and Technological Research Council of Turkey (TUBITAK) and the French Embassy in Turkey are gratefully acknowledged for the bilateral Parteneriat Hubert Curien between Turkey and France (project Bosphorus 109M356/26268ZM). The authors thank the Regional Council of Auvergne (Conseil Regional d'Auvergne) and the European Fund for Regional Economic Development (FEDER) for supporting the CA3D project.
dc.identifier.doi10.1021/mp400207v
dc.identifier.endpage3716
dc.identifier.issn1543-8384
dc.identifier.issn1543-8392
dc.identifier.issue10
dc.identifier.orcid0000-0002-6807-0609
dc.identifier.orcid0000-0003-3347-4846
dc.identifier.orcid0000-0002-0388-8338
dc.identifier.pmid23937202
dc.identifier.scopus2-s2.0-84888375498
dc.identifier.scopusqualityQ1
dc.identifier.startpage3706
dc.identifier.urihttps://doi.org/10.1021/mp400207v
dc.identifier.urihttps://hdl.handle.net/20.500.14854/8567
dc.identifier.volume10
dc.identifier.wosWOS:000326319900017
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAmer Chemical Soc
dc.relation.ispartofMolecular Pharmaceutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20251020
dc.subjectphthalocyanine
dc.subjectchalcone
dc.subjectphotodynamic therapy
dc.subjectantivascular
dc.subjectdual effect
dc.titleAssessing the Dual Activity of a Chalcone-Phthalocyanine Conjugate: Design, Synthesis, and Antivascular and Photodynamic Properties
dc.typeArticle

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