Fast-dissolving electrospun gelatin nanofibers encapsulating ciprofloxacin/cyclodextrin inclusion complex

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dc.contributor.authorAytac, Zeynep
dc.contributor.authorIpek, Semran
dc.contributor.authorErol, Ismail
dc.contributor.authorDurgun, Engin
dc.contributor.authorUyar, Tamer
dc.date.accessioned2025-10-29T11:29:39Z
dc.date.issued2019
dc.departmentFakülteler, Temel Bilimler Fakültesi, Kimya Bölümü
dc.description.abstractElectrospun gelatin nanofibrous matrix encapsulating ciprofioxacin (CIP)/hydroxypropyl-beta-cyclodextrin (HP beta CD)-inclusion complex (IC) was produced via electrospinning method. Computational modeling indicated that van der Waals forces are the most significant driving forces for the complexation and hydrophobic moiety (piperazinyl) of CIP, which was included in the cavity of HP beta CD. The FTIR and XRD studies indicated the formation of CIP/HP beta CD host/guest complexation, FTIR also suggested that hydrophobic moiety of CIP is in the HP beta CD cavity in parallel with the computational modeling results. The phase solubility diagram demonstrated that the solubility of CIP was enhanced after complexation with HP beta CD. SEM images showed that electrospun gelatin nanofibers encapsulating CIP/HP beta CD-IC have bead-free morphology with a diameter of (similar to)90 nm. The gelatin nanofibrous mat loaded with CIP/HP beta CD-IC has exhibited fast-dissolving character in water compared to gelatin/CIP nanofibrous mat due to the enhanced wettability of the nanofibrous mat by HP beta CD and improvement achieved in the solubility of CIP.
dc.description.sponsorshipNational Center for High Performance Computing of Turkey (UHeM) [5003622015]
dc.description.sponsorshipTurkish Academy of Sciences within Outstanding Young Scientists Award Program (TUBA-GEBIP)
dc.description.sponsorshipTUBITAK-BIDEB
dc.description.sponsorshipTUBITAK
dc.description.sponsorshipThe computational resources are provided by TUBITAK ULAKBIM, High Performance and Grid Computing Center (TR-Grid e Infrastructure) and the National Center for High Performance Computing of Turkey (UHeM) under grant no. 5003622015. Dr. Durgun acknowledge the financial support from the Turkish Academy of Sciences within Outstanding Young Scientists Award Program (TUBA-GEBIP). Dr. Aytac thanks to TUBITAK-BIDEB and TUBITAK for the PhD scholarship.
dc.identifier.doi10.1016/j.colsurfb.2019.02.059
dc.identifier.endpage136
dc.identifier.issn0927-7765
dc.identifier.issn1873-4367
dc.identifier.orcid0000-0002-0639-5862
dc.identifier.orcid0000-0002-3989-4481
dc.identifier.pmid30852264
dc.identifier.scopus2-s2.0-85062458647
dc.identifier.scopusqualityQ1
dc.identifier.startpage129
dc.identifier.urihttps://doi.org/10.1016/j.colsurfb.2019.02.059
dc.identifier.urihttps://hdl.handle.net/20.500.14854/11212
dc.identifier.volume178
dc.identifier.wosWOS:000471084400016
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofColloids and Surfaces B-Biointerfaces
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20251020
dc.subjectElectrospinning
dc.subjectNanofibers
dc.subjectCiprofloxacin
dc.subjectHydroxypropyl-beta-cyclodextrin (HP beta CD)
dc.subjectInclusion complex
dc.subjectComputational modeling
dc.titleFast-dissolving electrospun gelatin nanofibers encapsulating ciprofloxacin/cyclodextrin inclusion complex
dc.typeArticle

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