Synthesis, Structure and Biological Activity of Coordination Compounds of Copper, Nickel, Cobalt, and Iron with EthylN'-(2-Hydroxybenzylidene)-N-prop-2-en-1-ylcarbamohydrazonothioate

Abstract

N-(Prop-2-en-1-yl)hydrazonocarbothioamide reacts with iodoethane in methanol with further addition of 2-hydroxybenzaldehyde to form hydroiodide of carbamohydrazonothioate (HL center dot HI). The coordination compounds were obtained by interaction of HL or HL center dot HI with copper, nickel, cobalt and iron salts CuLX center dot nH(2)O [X = Cl-, Br-, NO3-;n= 0-1], Ni(L)(2)center dot HI center dot CH3OH, Co(L)(2)X [X = I-, NO3-] and Fe(L)(2)NO3. The structures of three complexes were established by single crystal X-ray analysis. The synthesized complexes exhibit selective antimicrobial and antifungal activity against a series of standard microorganisms and fungi in the concentration range of 30-500 mu g/mL. In addition, nickel and iron complexes selectively inhibit the growth and proliferation of cancer cells and do not adversely affect normal cells.