Antimicrobial activity of a quaternized BODIPY against Staphylococcus strains

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dc.contributor.authorTekdas, Duygu Aydin
dc.contributor.authorViswanathan, Geetha
dc.contributor.authorTopal, Sevinc Zehra
dc.contributor.authorLooi, Chung Yeng
dc.contributor.authorWong, Won Fen
dc.contributor.authorTan, Grace Min Yi
dc.contributor.authorZorlu, Yunus
dc.date.accessioned2025-10-29T11:20:03Z
dc.date.issued2016
dc.departmentFakülteler, Temel Bilimler Fakültesi, Kimya Bölümü
dc.description.abstractA novel BODIPY derivative was designed for biomedical applications. Its mono-quaternized structure ensured its water-solubility and suitable amphiphilicity. Showing no singlet oxygen generation to avoid damage to healthy cells, this new derivative proved to be an extremely promising antimicrobial agent, with activity equal or superior to ampicillin against MRS Staphylococcus strains with no short-term resistance issue. Its activity against MSS Staphylococcus strains was largely superior to those of ampicillin and reached the activity of vancomycin against MSS S. epidermidis. This latter result is in particular extremely promising for the treatment of hospital-acquired infections. Also the fluorescence properties of BODIPY allowed imaging of the uptake.
dc.description.sponsorshipUniversity of Malaya High Impact Research (HIR) from Ministry of Higher Education, Malaysia [UM.C/625/1/HIR/MOHE/MED/17, UM.C/625/1/HIR/MOHE/MED/33]
dc.description.sponsorshipGebze Technical University-The Commission of Scientific Research Projects [2011-A-13]
dc.description.sponsorshipThis project was partly supported by the University of Malaya High Impact Research (HIR) grants (UM.C/625/1/HIR/MOHE/MED/17 and UM.C/625/1/HIR/MOHE/MED/33) from the Ministry of Higher Education, Malaysia and by the Gebze Technical University-The Commission of Scientific Research Projects (Project BAP no: 2011-A-13).
dc.identifier.doi10.1039/c5ob02477c
dc.identifier.endpage2670
dc.identifier.issn1477-0520
dc.identifier.issn1477-0539
dc.identifier.issue9
dc.identifier.orcid0000-0001-5535-2829
dc.identifier.orcid0000-0003-3602-4007
dc.identifier.orcid0000-0002-0388-8338
dc.identifier.orcid0000-0002-0768-2222
dc.identifier.orcid0000-0003-1082-1956
dc.identifier.orcid0000-0001-7192-1470
dc.identifier.orcid0000-0003-2811-1872
dc.identifier.pmid26831779
dc.identifier.scopus2-s2.0-84983132716
dc.identifier.scopusqualityQ2
dc.identifier.startpage2665
dc.identifier.urihttps://doi.org/10.1039/c5ob02477c
dc.identifier.urihttps://hdl.handle.net/20.500.14854/8433
dc.identifier.volume14
dc.identifier.wosWOS:000371041500010
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherRoyal Soc Chemistry
dc.relation.ispartofOrganic & Biomolecular Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20251020
dc.subjectAureus
dc.subjectDiscovery
dc.subjectProbes
dc.subjectDyes
dc.titleAntimicrobial activity of a quaternized BODIPY against Staphylococcus strains
dc.typeArticle

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