Synthesis and characterization of novel hydrazide-hydrazones and the study of their structure-antituberculosis activity

Basit Öğe Kaydı
dc.contributor.authorBedia, Kocyigit-Kaymakcioglu
dc.contributor.authorElcin, Oruc
dc.contributor.authorSeda, Unsalan
dc.contributor.authorFatma, Kandemirli
dc.contributor.authorNathaly, Shvets
dc.contributor.authorSevim, Rollas
dc.contributor.authorDimoglo, Anatholy
dc.date.accessioned2025-10-29T11:28:00Z
dc.date.issued2006
dc.departmentFakülteler, Temel Bilimler Fakültesi, Kimya Bölümü
dc.description.abstractA series of hydrazide-hydrazones, based on a series of 4-substituted benzoic acid, were synthesized, and their structures were elucidated and screened for the antituberculosis activity against Mycobacterium tuberculosis H37Rv with the help of the BACTEC 460 radiometric system. Compound 3. 4-fluorobenzoic acid [((5-nitro)thiophen-2yl) methylene]hydrazide showed the highest inhibitory activity in this series. The search of pharmacophores was done by means of the Electronic-Topological Method (ETM). The model developed in this study is supposed to be applied to the design, preparation and screening of new compounds of similar structure in order to further test and optimize the model with the eventual goal of preparing new anti-tubercular agents. (c) 2006 Elsevier Masson SAS. All rights reserved.
dc.identifier.doi10.1016/j.ejmech.2006.06.009
dc.identifier.endpage1261
dc.identifier.issn0223-5234
dc.identifier.issn1768-3254
dc.identifier.issue11
dc.identifier.orcid0000-0001-6840-9660
dc.identifier.pmid16919372
dc.identifier.scopus2-s2.0-33751032349
dc.identifier.scopusqualityQ1
dc.identifier.startpage1253
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2006.06.009
dc.identifier.urihttps://hdl.handle.net/20.500.14854/11007
dc.identifier.volume41
dc.identifier.wosWOS:000242454100004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier
dc.relation.ispartofEuropean Journal of Medicinal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20251020
dc.subjectantituberculosis activity
dc.subjecthydrazide-hydrazones
dc.subjectstructure-activity relationships
dc.titleSynthesis and characterization of novel hydrazide-hydrazones and the study of their structure-antituberculosis activity
dc.typeArticle

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