Synthesis, Anticancer Evaluation and Pharmacokinetic Studies of Quinoline-Triazole Hybrid Derivatives

Abstract

Synthesis of effective and target-selective biologically active molecules through conjugation of diversely substituted triazoles and 5-aminoquinoline was achieved successfully with 1,4-disubstituted regioisomer products in the 3+2 cycloaddition reaction, as expected. Seven quinoline-1,2,3-triazole hybrid compounds which bear different substituent groups were subjected to FTIR, (HNMR)-H-1, (CNMR)-C-13 and MALDI-MS spectroscopic characterization methods. All quinoline-1,2,3-triazole hybrid derivatives (8 a-g) were explored for their anti-cancer activity towards Human urinary bladder carcinoma (T24) cells through cell viability, fluorescent imaging and colony formation analyses. Some chemical reactivity potentials and the pharmacokinetic properties of the quinoline-1,2,3-triazole hybrid compounds were analyzed. The frontier molecular orbital energies gap and chemical behaviour indices based on HOMO and LUMO energy values were analyzed via in-silico methods. All in vitro and in silico results are in agreement that quinoline-triazole derivative 8 f has potent anticancer activity and could serve for further investigation to enhance its potential biological activities.