Bisphthalonitrile with a Disulfide-Based Linker and its Dimethylene Analogue: Comparative Structural Insights

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dc.contributor.authorAlpugan, Serkan
dc.contributor.authorEkineker, Gulcin
dc.contributor.authorAhsen, Vefa
dc.contributor.authorBerber, Savas
dc.contributor.authorOnal, Emel
dc.contributor.authorDumoulin, Fabienne
dc.date.accessioned2025-10-29T11:08:58Z
dc.date.issued2016
dc.departmentFakülteler, Temel Bilimler Fakültesi, Kimya Bölümü
dc.description.abstractPhthalonitriles are key precursors of phthalocyanines. Self-quenching dimeric phthalocyanines likely to be cleaved into monomeric species are of potential interest for tumour-site activated photosensitisers. Disulfide linkers can be specifically cleaved in tumoral tissue do to their reductive nature. Hence, a disulfide-linked phthalonitrile was designed to serve as further precursor of specifically tumour-activatable phthalocyanine-based photosensitising systems. Bisphthalonitrile with a disulfide-based linker and its dimethylene analogue were comparatively analyzed on a spectroscopic point of view as well as with DFT calculations. A thorough crystallographic analysis of the disulfide-linked derivative was conducted.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [214Z099]
dc.description.sponsorshipThe Scientific and Technological Research Council of Turkey (TUBITAK) is gratefully acknowledged (project 214Z099).
dc.identifier.doi10.3390/cryst6080089
dc.identifier.issn2073-4352
dc.identifier.issue8
dc.identifier.orcid0000-0002-0388-8338
dc.identifier.scopus2-s2.0-84983335624
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/cryst6080089
dc.identifier.urihttps://hdl.handle.net/20.500.14854/5609
dc.identifier.volume6
dc.identifier.wosWOS:000384529100006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofCrystals
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20251020
dc.subjectbisphthalonitrile
dc.subjectdisulfide
dc.subjectcomparative characterization
dc.subjectsingle-crystal
dc.subjectDFT calculations
dc.subjectstructure optimization
dc.titleBisphthalonitrile with a Disulfide-Based Linker and its Dimethylene Analogue: Comparative Structural Insights
dc.typeArticle

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