Synthesis and characterization of some fused tricyclic spermidine derivatives of cyclotriphosphazene

Abstract

A number of derivatives of 6-chloro-2, 2-X-2-1, 3, 5, 7, 11, 16-hexa aza-4,6-diphosphatricyclohexadeca-2, 4, 6-triene {X=SPh, [OCH2(CF2)(2)CH2O](0.5), pyr, NMe2, NHPrn, Ph, NHBut} have been synthesised using two different reaction routes (1, 2) giving rise to penta-substituted-mono-chloro-compounds. The remaining chlorine atom in these products was reluctant to react with neutral nitrogen nucleophiles. The structures of the compounds were determined by elemental analysis, mass spectrometry and by H-1 and P-31-NMR spectrocsopy.