Synthesis, cytotoxicity and apoptosis of cyclotriphosphazene compounds as anti-cancer agents

Basit Öğe Kaydı
dc.contributor.authorYildirim, Tuba
dc.contributor.authorBilgin, Kemal
dc.contributor.authorCiftci, Gonul Yenilmez
dc.contributor.authorEcik, Esra Tanriverdi
dc.contributor.authorSenkuytu, Elif
dc.contributor.authorUludag, Yildiz
dc.contributor.authorTomak, Leman
dc.date.accessioned2025-10-29T11:27:59Z
dc.date.issued2012
dc.departmentFakülteler, Temel Bilimler Fakültesi, Kimya Bölümü
dc.description.abstractIn the present study, a number of new dispirobino and dispiroansa spermine derivatives of cyclotriphosphazene (8-10, 13) were synthesized and characterized by elemental analysis, mass spectrometry, H-1 and P-31 NMR spectroscopy. At first, in vitro cytotoxic activity of cyclotriphosphazene compounds (1-14) against HT-29 (human colon adenocarcinoma), Hep2 (Human epidermoid larynx carcinoma), and Vero (African green monkey kidney) cell lines was investigated. Our study showed that most of these compounds stimulate apoptosis and they have cytotoxic effects for HT-29 and Hep2 cells. Additionally, these compounds (1-14) were investigated for their antibacterial activity against gram-positive (Staphylococcus aureus), gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria and for their antifungal activity against Candida albicans, and were shown to be inactive. (C) 2012 Elsevier Masson SAS. All rights reserved.
dc.description.sponsorshipScientific and Technical Research Council of Turkey TUBITAK [108T355]
dc.description.sponsorshipThe authors thank the Scientific and Technical Research Council of Turkey for financial support TUBITAK (Grant 108T355). We are grateful to Dilek USTA for technical assistance for use of the flow cytometer at the Department of Hematology, Ondokuz Mayis University Hospital, Samsun.
dc.identifier.doi10.1016/j.ejmech.2012.03.018
dc.identifier.endpage220
dc.identifier.issn0223-5234
dc.identifier.issn1768-3254
dc.identifier.orcid0000-0002-3579-8062
dc.identifier.orcid0000-0003-2181-2457
dc.identifier.pmid22483088
dc.identifier.scopus2-s2.0-84860328555
dc.identifier.scopusqualityQ1
dc.identifier.startpage213
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2012.03.018
dc.identifier.urihttps://hdl.handle.net/20.500.14854/11006
dc.identifier.volume52
dc.identifier.wosWOS:000304291600020
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier
dc.relation.ispartofEuropean Journal of Medicinal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20251020
dc.subjectCyclotriphosphazene
dc.subjectSpermine derivatives
dc.subjectBiological activity
dc.subjectCytotoxic activity
dc.subjectApoptosis
dc.titleSynthesis, cytotoxicity and apoptosis of cyclotriphosphazene compounds as anti-cancer agents
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Temel Bilimler Fakültesi Koleksiyonu