Two new eudesmane-type sesquiterpene derivatives from Lecokia cretica (Lam.) DC

Abstract

Two new sesquiterpene glucosides, 1 alpha,6 beta,9 beta-trihydroxy-eudesm-4(15)-en-1,6-O-beta-diglucopyranoside (1) and 1 alpha,6 beta,9 beta-trihydroxy-eudesm-3-en-1,6-O-beta-diglucopyranoside (2) were obtained along with the 1 alpha,6 beta,9 beta-trihydroxy-5,10-bis-epi-eudesm-3-en-6-O-beta-D-glucopyranoside (3), chlorogenic acid (4), luteolin 7-O-rutinoside (5) and luteolin 7-O- glucoside (6) from the whole plant parts of Lecokia cretica. Their structures were determined on the basis of 1 D, 2 D NMR and HRMS analyses. The in vitro cytotoxic activity of compounds 1-3 against human lung cancer cells (A549) and normal human lung cells (BEAS-2B) was determined using the MTT colorimetric assay. All the tested eudesmane derivatives were found to be inactive.