Design of an amphiphilic porphyrin exhibiting high in vitro photocytotoxicity

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dc.contributor.authorTopkaya, Derya
dc.contributor.authorLafont, Dominique
dc.contributor.authorPoyer, Florent
dc.contributor.authorGarcia, Guillaume
dc.contributor.authorAlbrieux, Florian
dc.contributor.authorMaillard, Philippe
dc.contributor.authorBretonniere, Yann
dc.date.accessioned2025-10-29T11:20:04Z
dc.date.issued2016
dc.departmentFakülteler, Temel Bilimler Fakültesi, Kimya Bölümü
dc.description.abstractA porphyrin monosubstituted by three triethyleneglycol chains grafted on a pentaerythritol skeleton was designed to display an optimized amphiphilicity for an enhanced cellular uptake and thus to exert enhanced photocytotoxicity. This porphyrin proved to be an excellent photosensitiser with submicromolar IC50.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [114Z090]
dc.description.sponsorshipThe Scientific and Technological Research Council of Turkey (TUBITAK) is gratefully acknowledged for the funding of these studies (project 3001, number 114Z090). We are very grateful to Marine SCOAZEC and Marie-Noelle SOLER from the imaging plateform PICT-IBISA@ORSAY (Institut Curie, Orsay, France) for technical assistance in the use of the Leica confocal SP5 system.
dc.identifier.doi10.1039/c5nj02716k
dc.identifier.endpage2050
dc.identifier.issn1144-0546
dc.identifier.issn1369-9261
dc.identifier.issue3
dc.identifier.orcid0000-0002-5403-1326
dc.identifier.orcid0000-0002-0388-8338
dc.identifier.orcid0000-0003-1191-6287
dc.identifier.scopus2-s2.0-84960539072
dc.identifier.scopusqualityQ2
dc.identifier.startpage2044
dc.identifier.urihttps://doi.org/10.1039/c5nj02716k
dc.identifier.urihttps://hdl.handle.net/20.500.14854/8435
dc.identifier.volume40
dc.identifier.wosWOS:000372425600022
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherRoyal Soc Chemistry
dc.relation.ispartofNew Journal of Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20251020
dc.subjectPhotodynamic Therapy
dc.subjectPhthalocyanine
dc.subjectPhotosensitizers
dc.subjectNanoparticles
dc.subjectConjugate
dc.subjectMembrane
dc.subjectYields
dc.titleDesign of an amphiphilic porphyrin exhibiting high in vitro photocytotoxicity
dc.typeArticle

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