Cyclotriphosphazene, a scaffold for 19F MRI contrast agents

Abstract

A cyclotriphosphazene substituted with six 3,5-bis(trifluoromethyl) benzyloxy units was designed as a novel F-19 MRI contrast agent. The resulting molecule has 36 magnetically equivalent fluorine atoms and exhibited suitable MRI properties with high imaging sensitivity, confirming the proof-of-concept as a convenient scaffold for the production of new F-19 MRI contrasts agents. (C) 2017 Elsevier Ltd. All rights reserved.